Pharm. D. Syllabus (Hamdard University) : Pharm. D. 5th Prof. 1st Semester

Pharm. D. Fifth Professional

First Semester

Pharmaceutical Chemistry

Medicinal Chemistry – III (Theory)

PHC-701                                                                                                                      Cr. Hrs. 3

1.   General Properties, Chemistry (General methods of determination, the structure & isolation from natural source), Biological Action, Structure Activity Relationship And Therapeutic Applications Of The Following:

1.1 Anti-neoplastic Agents: Tamoxifen, Fluorouracil, Mercapturine, Methotrexate and Vincristine.

1.2 Sedatives and Hypnotics: Benzodiazepines, Barbiturates, Paraldehyde, Glutethimide, Chloral hydrate, and alcohols.

1.3 Anaesthetics: Local anaesthetics (Procaine, Lignocaine, Eucaine, Cocaine and Benzocaine), General anaesthetics (Cyclopropane, Halothane, Nitrous oxide, Chloroform, Thiopental Sodium, Ketamine, Methohexital, Thioamylal Sodium, Fantanyl Citrate, Tribromo ethanol).

1.4 Analgesics and Antipyretics: Paracetamol, Salicylic acid analogues, Quinolines derivatives, Pyrazolone and Pyrazolodiones, Narylanthranilic acids, Aryl and heteroaryl acetic acid derivatives.

2.   General Properties, Chemistry, Biological Action, Structure Activity Relationship and Therapeutic Applications of the Following:

2.1 Anti-tubercular Drugs:

2.1.1       Ethambutol,

2.1.2       Isonicotinic acid

2.1.3       Hydrazid

2.1.4       Rifampacin,

2.1.5       Thioguanine,

2.1.6       Pyrazinamide,

2.1.7       Cycloserine,

2.1.8       Ethunamide,

2.1.9       Cytarabine,

2.1.10  5- Flourouracil

2.1.11  Dacarbazine.

2.2 Antiviral Drugs:

2.2.1       Acyclovir,

2.2.2       Tromantadine Hydrochloride

2.2.3       Ribavirin.

2.3 Immunosuppressant Agents:

2.3.1       Azathioprine

2.3.2       Cyclosporin.

3.   DNA Recombinant technology/genetic engineering (with reference to drug designing).

4.   To study the biosynthesis, drug designing and action of the following.

Autocoids such as prostaglandins, leukotrenes and eicosanoids. Adrenergic and cholinergic agents, neurotransmitters, receptors, agonists and antagonists.

Pharmaceutics

Bio-Pharmaceutics (Lab)

PHT-705                                                                                                                      Cr. Hrs. 2

Note : Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g.

1.      Blood Sampling Techniques: In Laboratory Animals like dog, rabbits, mice etc In human beings.

2.      Plasma level-time curve: Determination of Pharmacokinetic parameters.

3.      In-vitro dissolution studies

4.      Optional dose determination.

5.      Measurement of rate of Bioavailability,

6.      Determination of plasma protein binding.

7.      Determination of relative and absolute bioavailability.

8.      Urinary sampling techniques.

9.      In Laboratory animals. In humans. Renal excretion of drugs or drug disposition.

Pharmaceutics

Clinical Pharmacy – III (Theory)

PHT-707                                                                                                                      Cr. Hrs. 3

1.      Rational Use Of Drugs

1.1.  Rational Presribing, Rational Dispensing, Problems of Irrational Drug Use, Learning about drug use problem, Sampling to study drug use, Indicators of drug use.

2.      Introduction To Essential Drugs

2.1.  Criteria for selection, Usage and Advantages.

3.      Drug Utilzation Evaluation & Drug Utilization Review (DUE/DUR)

3.1.  Development of protocol of use of few very low therapeutic index drug groups like Steroids, Vancomycin and Cimetidine.

4.      Drug Abuse & Misuse.

5.      Practical Pharmacokinetics

5.1.  Therapeutic Drug Monitoring of Digoxin, Theophyline, Gentamycin, Lithium, Phenytoin, Cabamazepine, Phenobarbitone, Primidone, Walporic Acid, Cyclosporins and Vancomycin.

6.      Pharmacoeconomic Studies.

Pharmaceutics

Clinical Pharmacy (Lab)

PHT-709                                                                                                                      Cr. Hrs. 2

Clerkship in a Clinical setting. A project related to Clinical Pharmacy Practices will be completed by the students and will be evaluated by the external examiner.

Pharmaceutics

Pharmaceutical Management and Marketing –I (Theory)

PHT-711                                                                                                                      Cr. Hrs. 3

1.      Management:

1.1.  Nature and Principles of Management.

1.2.  Types and Functions of Managers.

1.3.  Planning

1.3.1.     Purpose and types of Planning

1.3.2.     Steps in Planning.

1.4.  Organizing

1.5.  Management Control Systems

1.5.1.     Purpose

1.5.2.     Steps in the Control Process

1.5.3.     Forms of Operations control

1.5.4.     Requirements for adequate control

1.5.5.     Critical control points and standards.

1.6.  Motivation.

1.7.  Innovation and creativity

1.8.  Communication

2.      Production Management:

2.1.  Material Management.

Pharmaceutics

Pharmaceutical Quality Control – II (Theory)

PHT-713                                                                                                                      Cr. Hrs. 3

1.      Biological Assays:

1.1.  Biological methods, Standard preparations and units of activity, Bioassay of antibiotics, Bioassay of insulin injection, Assay of prepared digitalis and Assay of Vitamin D.

2.      Alcohol Determiantion:

2.1.  Alcoholometric methods, Problem during distillation of alcohol, Method for liquids containing less than 30% or more than 30% alcohol and special treatment before distillation.

3.      Alkaloidal Drug Assay:

3.1.  Weighing for assay, Extraction of drugs, Maceration, Percolation, Continuous extraction, Purification of Alkaloids and determination of alkaloids.

4.      Miscellaneous Determinations and Tests:

4.1.  Determination of weight/ml, Water/Moisture content, Loss on Drying, Toxicity tests & Identification tests, Evaluation of Ointments, Ash contents and Alkalinity of Glass.

5.      Validation of Pharmaceutical Process

5.1.  Control of components and drug product containers and doses.

5.2.  Production and process controls.

5.3.  Packaging and labelling controls.

5.4.  Holding and distribution.

5.5.  Repackaging and Re-labelling.

5.6.  Regulating basis for person validation

5.7.  Sterile product validation

5.8.  Validation of solid dosage form.

5.9.  Process validation and quality assurance.

5.10. Prospective process validation

5.11. Validation for water system for sterile and non-sterile products

5.12. Cleaning validation

5.13. Equipment validation

5.14. Process validation of raw materials

5.15. Analytical method validation.

Pharmaceutics

Pharmaceutical Technology – I (Theory)

PHT-715                                                                                                                      Cr. Hrs. 3

1.      Principles of Pharmaceutical Formulation and Dosage Form Design:

1.1.  Product Formulation, Need for Dosage Form and Preformulation Studies.

2.      Formulation Development

2.1.  Pharmaceutical Aerosoles

2.2.  Ophthalmic Preparations

2.3.  Parenteral Preparations.

3.      Advanced Formulation Techniques

3.1.  Development of a formulation methodology and flow plan for the new product

3.2.  New technologies in drug delivery system.

4.      Novel Drug Delivery Systems:

4.1.  Introduction to the Drug Carrier:

4.1.1.     Liposomes

4.1.2.     Niosomes

4.1.3.     Biodegradable polymers.

4.2.  Active & Passive Drug Delivery System.

4.3.  Other Novel GIT Systems.